The effect of these channels on neuron firing level in nigral dopamine neurons is this sort of that administration in the KATP-channel antagonist glibenclamide in a 100 nM focus was able to boost neuron firing rate by 34% (Garcia de Arriba et al 1999; Avshalumov et al 2005). KATP-channel exercise also seems to get elevated by extracellular adenosin
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